ANNOUNCEMENTS TRIALS COMBINING AZT AND DDI NOW RECRUITING

New clinical trials investigating the safety and
effectiveness of various AZT/ddI combinations are open to
participation at sites in Boston (Principal Investigator Paul
Skolnik, M. D.), Miami (Margaret Fischl, M. D.), Seattle
(Lawrence Corey, M. D.), and San Francisco (Don Northfelt, M.
D. and Lawrence Kaplan, M. D.). Larger trials comparing ddI to
AZT have been in place for some time, but these are the first
trials to combine the two drugs.

These are Phase I (testing for toxicity) studies, and will
try five separate dosage combinations ranging from 45 mg of ddI
twice a day given with 50 mg of AZT three times daily, to 250 mg
of ddI twice a day with 200 mg of AZT three times daily. No
placebos are involved. The San Francisco trial only (not the
trials at the other sites) will include three separate lumbar
punctures over the course of the study, to measure the quantity
of drug reaching the cerebrospinal fluid. They will be done by
experienced physicians and should pose minimal discomfort.

For information regarding entry criteria, interested persons
may call Marca Wilk, R. N., at the New England Medical Center,
617/956-5114, beeper 1267; the protocol screening number at the
University of Miami AIDS Clinical Research Unit, 305/547- 3838;
Jeanne Conley, R. N., at Harborview Medical Center, 206/223-3184;
or Kit Boggio, R. N., at San Francisco General Hospital,
415/821-5089. This trial is sponsored by Burroughs- Wellcome.

Note: This is a small study, and only a few positions are
open at each center.



START-UP GRANTS FOR CARE OR SUPPORT TO PEOPLE WITH AIDS

People Taking Action Against AIDS (PTAAA), which runs a
successful fundraiser each summer in Bellport, Long Island, is
accepting applications for start-up grants for newly-formed
groups offering care or support to people with AIDS especially
groups outside of major metropolitan areas.

Applicants should submit a brief description of their
organization's activities and goals no later than August 1. Send
requests to Don Hall, PTAAA, Box 378, Bellport, New York, 11713.
For more information, call 212/505-1350.

* Note: This summer's event, "Sunday by the Bay," will be
July 8th in Bellport. For directions and ticket information,
call 516/286-1020.



STATEMENT OF PURPOSE

AIDS TREATMENT NEWS reports on experimental and complementary
treatments, especially those available now. It collects
information from medical journals, and from interviews with
scientists, physicians, and other health practitioners, and
persons with AIDS or ARC.

Long-term survivors have usually tried many different treatments,
and found combinations which work for them. AIDS Treatment News
does not recommend particular therapies, but seeks to increase
the options available.

We also examine the ethical and public-policy issues around AIDS
treatment research and treatment access.