d4T Dose Clarification

Our interview with Dr. Conant published in issue #228, August
4, 1995, left some readers confused about the d4T dose Dr.
Conant is using. For some patients, he increases the dose
until it is twice the dose recommended by the FDA in the
product labeling. The following statement in the interview is
correct:

"Dr. Conant: If there is evidence of disease progression, we
are first treating many patients with very high dose d4T. The
dose I usually start with is 20 mg. twice a day; then I have
the patient increase it by 20 mg. each week, until they get
neuropathy, or until we get to 80 mg. twice a day. That is
twice the FDA-recommended dose."

But then the next paragraph includes the statement, "So if
patients can tolerate the dose, I go all the way up to 80 mg
per day." This should have read "80 mg per dose," not "per
day." AIDS TREATMENT NEWS regrets the confusion.